777 Memorial Drive From Mass. Turnpike: Take off exit 18 on the Massachusetts Turnpike, follow Cambridge sign, then go across the bridge. Take a right onto Memorial Drive. Follow Memorial drive for one block, the hotel is on the left at the intersection of Memorial Drive and Pleasant Street.
From Route 93: Take off Route 93 at exit Storrow Drive, follow Cambridge/Memorial Drive sign, then go across the bridge passing Musuem of Sciences. Take a left onto Memorial Drive. Follow Memorial drive, pass MIT then go under the bridge (Massachusetts Ave). Pass Hyatt Regency Hotel, Micro Center, and Polaroid, the hotel is on the right at the intersection of Memorial Drive and Pleasant Street.
From Route 95:
Get onto Route 93 to Boston or get onto Route 1 South Boston. Then follow the direction from route 93.